‘The improvements we saw were highly significant and clinically relevant,’ said Dr. Weaver. ‘Furthermore, our study was carried out at both smaller sized and large clinical practice sites, making our results generalizable highly. ‘ The analysis had some limitations, including a brief mean duration of active daily CPAP treatment and a lesser mean duration of sham daily CPAP treatment . ‘Given the high prevalence of OSA, our study shows that there is significant worth in treating sleepy individuals with moderate to moderate disease,’ concluded Dr.Secondary efficacy endpoints included modification in mean 4-hour postprandial insulin amounts; fasting plasma levels of C-peptide, fructosamine, and glycosylated hemoglobin ; and incidence of hyperglycemia . Fifty-five sufferers were assigned to get alogliptin 25 , 100 , or 400 mg , or placebo once daily for 14 days. Sufferers received three standardized foods a day time and a snack after dosing on Days -1 , 1 and 14. Bloodstream and urine samples were collected through a day after Day time 1 and through 48 hours after Day 14.